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Investigación
IRAS – Infecciones Relacionadas con la Asistencia Sanitaria y Resistencias frente a Antimicrobianos
Líneas de investigación
Contenidos con Investigacion .
IRAS – Infecciones Relacionadas con la Asistencia Sanitaria y Resistencias frente a Antimicrobianos
- Investigación en la epidemiología de las Infecciones Relacionadas con la Asistencia Sanitaria (IRAS). Valorar la calidad asistencial en cirugías frecuentemente realizadas en España usando como indicador la incidencia de IRAS.
- Variación geográfica de la carga de enfermedad por IRAS en hospitales.
- Estimación del impacto de la organización hospitalaria en la incidencia de IRAS.
- Investigación en la epidemiología de las Resistencias a Antimicrobianos (RAM).
- Valoración de la idoneidad de los tratamientos antimicrobianos en pacientes mayores con patologías crónicas de base.
- Estimación de costes asociados al manejo de las infecciones de microrganismos resistentes.
- Generación de modelos de predicción de riesgo de infección y de riesgo de infección por microorganismo resistentes.
- El “convenio entre el Instituto de Salud Carlos III O.A., M.P. y Clínica Barceloneta S.A. para el desarrollo de actividades relacionadas con el estudio del impacto de los antimicrobianos en la incidencia de resistencias en pacientes mayores atendidos en hospitales de atención intermedia de Barcelona”. Número de expediente: RCN-CNU202400125 Vigente hasta el 04/10/2028
- El proyecto coordinado “Desarrollo de Infraestructuras ISCIII para la creación, estandarización y producción de fagos útiles en Infecciones bacterianas pulmonares crónicas. (DISCIII-Phage)” Número de expediente: COOP24CIII/00010. Vigente hasta el 30 de Junio de 2028. Programa COOPERA-ISCIII para la realización de proyectos coordinados estratégicos transversales en el marco de la AES intramural (AESI) 2024.
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Publicaciones destacadas
Blood-Based Lead Biomarkers and Sarcopenia Indicators in Older Adults
Koni A, Santos-Cuerva A, Sotos-Prieto M, Ortolá R, Olmedo P, García-Pérez J, Ramis R, Carballo-Casla A, Gil F, González-Palacios J, Pastor-Barriuso R, Navas-Acién A, Plans-Beriso E, Fernández-Navarro P, Rodríguez-Artalejo F, García-Esquinas E. Blood-Based Lead Biomarkers and Sarcopenia Indicators in Older Adults. J Cachexia Sarcopenia Muscle. 2026 Feb;17(1):e70179.
PUBMED DOIRisk of prostate cancer in the proximity of industrial installations: A multicase-control study in Spain (MCC-Spain).
García-Pérez J, Fernández de Larrea-Baz N, Lope V, Domínguez-Castillo A, Espinosa A, Dierssen-Sotos T, Contreras-Llanes M, Sierra MÁ, Castaño-Vinyals G, Tardón A, Jiménez-Moleón JJ, Molina-Barceló A, Aragonés N, Kogevinas M, Pollán M, Pérez-Gómez B. Risk of prostate cancer in the proximity of industrial installations: A multicase-control study in Spain (MCC-Spain). Sci Total Environ. 2024 Oct 10;946:174347.
PUBMED DOIIncreased trends in reported sexually transmitted infections according to age groups and sex in Spain, 2016–2022.
Hernando V, Lorusso N, Montaño C, Boone A LD, Garí A, Perez G, Viloria L, Morales R, Marcos H, Casabona J, Bellmut P, Vicente S, Pérez O, Miguel A, Barranco-Boada MI, Castilla J, Latasa P, Martínez E, Rivas AI, Castrillejo D, Villegas-Moreno T, Simón L, Diaz A, and STIs Study Group of National Epidemiological Surveillance Network. Infect Dis (Lond). 2025 Mar;57(3):247-255.
PUBMED DOIFirst report in two decades of ciguatera fish poisoning linked to small-sized fish consumption in the Canary Islands
Ana Hernández-Aceituno, Isabel Falcón García, Álvaro Torres Lana, Francisco M Martín León, María José Ramos-Sosa, Andres Sanchez-Henao, Carmen Varela Martínez, M Iluminada Negrín Díaz, Eneko Larumbe-Zabala, Jesús Ulises Cabrera García, Minerva Matos Cruz, Miguel Ángel González Cortes, María Fernanda Marín Barragán, Fernando Real Valcárcel.
PUBMED DOIHarmonization of alcohol use data and mortality across a multi-national HIV cohort collaboration.
Ingle SM, Trickey A, Lankina A, McGinnis KA, Justice A, Cavassini M, d' Arminio Monforte A, van Sighem A, Gill MJ, Crane HM, Obel N, Jarrin I, Wallner E, Guest J, Silverberg MJ, Vourli G, Wittkop L, Sterling TR, Satre DD, Burkholder GA, Costagliola D, Sterne JAC. Alcohol Clin Exp Res (Hoboken). 2025 Jan 8. doi: 10.1111/acer.15522. Epub ahead of print.
PUBMED DOIEpidemiología y carga de enfermedad por VRS en España. SiVIRA, temporadas 2021-22 y 2022-23.
Puma Olguin TC, Mazagatos C, Galindo-Carretero S, Vega-Piris L, Lozano-Álvarez M, Pérez-Gimeno G, et al. BES. 2024 May 6; 32(1):21-35.
DOIIndependent and combined effect of sitting time and physical activity on all-cause mortality in Spain: a population-based prospective study.
Granero-Melcón B, de la Cámara MÁ, Ortiz C, Martínez-Portillo A, Neira-León M, Galán I. Independent and combined effect of sitting time and physical activity on all-cause mortality in Spain: a population-based prospective study. Eur J Public Health. 2025 Jun 1;35(3):548-554.
PUBMED DOIDeterminants of cesarean section rates: A cross-sectional study of 4.9 million deliveries over 10 years.
Alonso-Colón M, Pérez-Gómez B, Ramis R. Determinants of cesarean section rates: A cross-sectional study of 4.9 million deliveries over 10 years. Eur J Obstet Gynecol Reprod Biol. 2025 Aug;312:114527.
PUBMED DOIInfants needed to immunise with nirsevimab to prevent one RSV hospitalisation, Spain, 2023/24 season.
Pastor-Barriuso R, Núñez O, Monge S; Nirsevimab Effectiveness Study Collaborators. Infants needed to immunise with nirsevimab to prevent one RSV hospitalisation, Spain, 2023/24 season. Euro Surveill. 2025 Feb;30(6):2500040.
PUBMED DOIVaricela en España, 1997-2023. Análisis preliminar del impacto de la vacunación universal en la infancia.
Torres de Mier MV, Masa-Calles J. Boletín Epidemiológico Semanal. 2025;33(1):45-57.
DOIThe relevance of WHO behavioural health insights
Romay Barja M, Bilos IB, Bratu EC, Falcón M, Forjaz MJ, Nagyova I, Niskanovic J, Osiptchik S, Rodríguez-Blázquez C, Sanders J, Takhirova F, de Arriga MT, Van der Biest L. The relevance of WHO behavioural health insights. Lancet. 2025 Jun 7;405(10494):2045-2046
PUBMED DOITrends of non-lethal intentional self-harm and suicide in Spain 2018-2023: a nationwide registry-based study
López-Cuadrado T, Mortier P, Alonso J, Martínez-Alés G. Trends of non-lethal intentional self-harm and suicide in Spain 2018-2023: a nationwide registry-based study. Lancet Reg Health Eur. 2025 Sep 27;58:101467.
PUBMED DOIMetal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain
Ayuso-Álvarez A, Nuñez O, Martín-Méndez I, Bel-Lán A, Tellez-Plaza M, Pérez-Gómez B, Galán I, Fernández-Navarro P. Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain. Environ Res. 2022 Mar;204(Pt D):112395.
PUBMED DOIPreveCan, an app for cancer prevention based on the 2018 WCRF/AICR guidelines: development and usability
Ruiz-Moreno E, García-Pérez J, Lope V, Núñez O, González-Sánchez M, Chaplin A, Romaguera D, Fernández-Navarro P, Pollán M, Castelló-Pastor A. PreveCan, an app for cancer prevention based on the 2018 WCRF/AICR guidelines: development and usability. Gac Sanit. 2026 Mar 19;40:102565.
PUBMED DOIGrowth Differentiation Factor 15 as a Biomarker of Cardiovascular Risk in Chronic Musculoskeletal Pain
León-González R, Ortolá R, Carballo-Casla A, Sotos-Prieto M, Buño-Soto A, Rodríguez-Sánchez I, Pastor-Barriuso R, Rodríguez-Artalejo F, García-Esquinas E. Growth Differentiation Factor 15 as a Biomarker of Cardiovascular Risk in Chronic Musculoskeletal Pain. J Gerontol A Biol Sci Med Sci. 2024 Aug 1;79(8):glae163.
PUBMED DOIMammographic density and exposure to air pollutants in premenopausal women: a cross-sectional study.
Jiménez T, Domínguez-Castillo A, Fernández de Larrea-Baz N, Lucas P, Sierra MÁ, Maeso S, Llobet R, Pino MN, Martínez-Cortés M, Pérez-Gómez B, Pollán M, Lope V, García-Pérez J. Mammographic density and exposure to air pollutants in premenopausal women: a cross-sectional study. Environ Health Prev Med. 2024;29:65.
PUBMED DOIExploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe.
Maurel M, Mazagatos C, Goerlitz L, Oroszi B, Hooiveld M, Machado A, et al. Vaccine. 2024 Jun 11;42(16):3547–54.
PUBMED DOIMarked increase in cryptosporidiosis cases, Spain, 2023. Euro Surveill. 2024;29(28):2300733.
Peñuelas Martínez M, Carmena D, Guzmán Herrador BR, et al.
DOIQuality of life of informal caregivers 50 years old and older in Spain by household living status: a descriptive study.
Bernal-Alonso A, Rodríguez-Blázquez C, Fernández-Carro C, Ayala A, Calderón-Larrañaga A, Forjaz MJ. Quality of life of informal caregivers 50 years old and older in Spain by household living status: a descriptive study. Sci Rep. 2025 Jul 1;15(1):21121.
PUBMED DOIUrban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator.
Sanz Olea E, Hernández JL, Artíñano B, Briz V, Karakitsios S, Sarigiannis D, García Dos Santos S, Nuñez-Corcuera B, Ramis R. Urban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator. PLoS One. 2025 May 7;20(5):e0322874.
PUBMED DOINon-genetic and genetic determinants of serum selenium and selenium species in the Aragon Workers Health Study.
Rodriguez-Hernandez Z, Paredes-Douton A, Galvez-Fernandez M, Grau-Perez M, Sotos-Prieto M, Rentero-Garrido P, Gonzalez-Estecha M, Llorente-Ballesteros MT, Gomez-Ariza JL, Callejon-Leblic B, Fernandez-Navarro P, Laclaustra M, Cenarro A, Civeira F, Glabonjat RA, Monleon D, Pastor-Barriuso R, Moreno-Franco B, Garcia-Barrera T, Tellez-Plaza M. Non-genetic and genetic determinants of serum selenium and selenium species in the Aragon Workers Health Study. Free Radic Biol Med. 2025 Jun;233:365-377.
PUBMED DOIEffectiveness of catch-up and at-birth nirsevimab immunisation against RSV hospital admission in the first year of life: a population-based case-control study, Spain, 2023/24 season
Núñez O, Olmedo C, (…), Pastor-Barriuso R, Monge S; Nirsevimab Effectiveness Study Collaborators. Effectiveness of catch-up and at-birth nirsevimab immunisation against RSV hospital admission in the first year of life: a population-based case-control study, Spain, 2023/24 season. Euro Surveill. 2025 Feb;30(5):2400596. doi: 10.2807/1560-7917.ES.2025.30.5.2400596. Erratum in: Euro Surveill. 2025 Apr;30(13).
PUBMED DOIEnfermedad Neumocócica Invasiva en España en 2023.
Soler Soneira M, Del-Águila-Mejía J, Acosta-Gutiérrez M, Sastre-García M, Amillategui- Dos-Santos R, Cano Portero R. BES [Internet]. 29 de julio de 2024 [citado 28 de agosto de 2024];32(2):74-93.
DOICharacteristics of adults who reported not having had COVID-19 in Spain after the first two years of the pandemic and associated factors.
Beca-Martínez MT, Ayala A, Falcón-Romero M, Rodríguez-Blázquez C, Benito-Llanes A, Forjaz MJ, Romay-Barja M. Characteristics of adults who reported not having had COVID-19 in Spain after the first two years of the pandemic and associated factors. J Infect Public Health. 2024 Mar;17(3):435-442.
PUBMED DOIAtlas of Cancer Mortality in Portugal and Spain (2003–2012)
Fernández-Navarro P, Roquette R, Nuñez O, de Sousa-Uva M, García-Pérez J, López-Abente G, Nunes B, González-Sánchez M, Dinis J, Carmona R, Rocha Rodrigues J, Aragonés N, Bento MJ, Castelló A, Rego R, Lope V, Henrique R, Boldo E, Pais A, Fernández de Larrea-Baz N, Bastos J, Ramis R, Carrito B, Pastor-Barriuso R, Miranda A, Pérez-Gómez B, Forjaz G, Matias Dias C & Pollán M. Atlas of Cancer Mortality in Portugal and Spain 2003-2012. National Institute of Health Doutor Ricardo Jorge (Portugal) and National Institute of Health Carlos III (Spain), 2021.
PUBMED DOIMammographic density and breast cancer pathological subtypes by menopausal status and body mass index
Fernández-Morata J, Pollán M, Fernández de Larrea-Baz N, Pachón-Olmos V, García-Pérez J, Castelló A, Sierra MÁ, Lucas P, Llobet R, Stradella A, Cantos B, Ramón Y Cajal T, Santisteban M, Seguí MÁ, Santaballa Bertrán A, Granja M, Camps-Herrero J, Recalde S, Nuñez-García B, Calvo Verges N, Pérez-Gómez B, Pastor-Barriuso R, Lope V. Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index. Breast Cancer Res. 2025 Oct 24;27(1):187.
PUBMED DOIGlyphosate exposure, muscular health and functional limitations in middle-aged and older adults
Jauregui-Zunzunegui S, Rodríguez-Artalejo F, Tellez-Plaza M, García-Esquinas E. Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults. Environ Res. 2024 Jun 15;251(Pt 1):118547.
PUBMED DOIResidential exposure to traffic pollution and mammographic density in premenopausal women.
Jiménez T, Domínguez-Castillo A, Fernández de Larrea-Baz N, Lucas P, Sierra MÁ, Salas-Trejo D, Llobet R, Martínez I, Pino MN, Martínez-Cortés M, Pérez-Gómez B, Pollán M, Lope V, García-Pérez J. Residential exposure to traffic pollution and mammographic density in premenopausal women. Sci Total Environ. 2024 Jun 10;928:172463.
PUBMED DOISIPrEP: a tool to monitor HIV pre-exposure prophylaxis in Spain.
Enferm Infecc Microbiol Clin (Engl Ed). 2025; 43(8):515-522. Iniesta C, Hernando V, Jarrín I, Pérez de la Cámara S, de la Torre J, Villanueva V, Mayorga MI, Belda J, Soteras M, Torres Lana A, Echevarria A, Monteagudo O, Marcos H, Ben Cheikh W, Portocarrero-Núñez JA, Álvarez-del Arco D, Diaz A, del Amo J y SIPrEP Working Group.
PUBMED DOIBrotes de transmisión alimentaria e hídrica en España, 2018-2022. BES [Internet]. 29 de julio de 2024 [citado 31 de octubre de 2024];32(2):61-73.
Sanz-Olea E, Peñuelas M, Guerrero-Vadillo M, Sastre-García M, Díaz O, Cano-Portero R, et al.
DOIShould we measure quality of life among people with HIV? A multicentre survey of physicians' opinions in Spain.
Izquierdo R, Suárez-García I, Gómez-García T, Marco-Sánchez C, Puente-Ferreiro J, Moreno C, Diaz A, Cabello-Clotet N, Vinuesa D, Blanco JL, Melús E, Gómez-Ayerbe C, Olalla J, Riera M, Bernardino JI, de López Bernaldo de Quirós JC, Moreno S, Jarrín I; CoRIS cohort.
PUBMED DOIComparative severity of COVID-19 cases caused by Alpha, Delta or Omicron SARS-CoV-2 variants and its association with vaccination.
Varea-Jiménez E, Aznar Cano E, Vega-Piris L, Martínez Sánchez EV, Mazagatos C, García San Miguel Rodríguez-Alarcón L, et al. Enfermedades Infecc Microbiol Clin Engl Ed. 2024 Apr;42(4):187–94.
PUBMED DOIChanges in mental health diagnosis and healthcare use in seven European countries before and during the COVID-19 pandemic (2017-21).
Rodríguez-Blazquez C, Aldridge SJ, Bernal-Delgado E, Calomfirescu C, Dolanski-Aghamanoukjan L, Estupiñán-Romero F, Gissler M, Beate G, Idavain J, Larose TL, Lyons RA, Mathis-Edenhofer S, Miller K, Misiņš J, Radulescu S, Rätsep M, Sagerschnig S, Sandu P, Šitcs J, Pavlovska Z, Thißen M, Tolonen H, Garriga C, Forjaz MJ. Changes in mental health diagnosis and healthcare use in seven European countries before and during the COVID-19 pandemic (2017-21). Eur J Public Health. 2025 Jun 1;35(3):484-490.
PUBMED DOIAssociation of miR-126-3p, miR-1260b and miR-374a-5p with the incidence of heart failure in a population-based cohort: the Hortega Follow-Up Study.
Grau-Perez M, Martinez-Arroyo O, Rubia-Martinez M, Flores-Chova A, Rodriguez-Hernandez Z, Fernández-Navarro P, Gonzalez-Neira A, Alonso MR, Pita G, Pineda S, Martin-Escudero JC, Ortega A, Redon J, Tellez-Plaza M, Cortes R. Association of miR-126-3p, miR-1260b and miR-374a-5p with the incidence of heart failure in a population-based cohort: the Hortega Follow-Up Study. Eur J Intern Med. 2025 May;135:118-125.
PUBMED DOI